Noter
Diasshow
Disposition
1
The Nordic Pediatric Renal Transplant Study Group
2
Pediatric renal transplantation in the Nordic countries
3
Pediatric renal transplantation in the Nordic countries
4
Pediatric renal transplantation in the Nordic countries
5
Pediatric renal transplantation in the Nordic countries
6
Pediatric renal transplantation in the Nordic countries Diagnoses
  • Congenital diseases 69%

    Malformations
    • Hypo-, dysplasia 18%
    • Obstructive uropathies 10%

  • Hereditary disorders
    • ARPKD   6%
    • Nefronoftis   9%
    • Finnish nephrosis 15%
7
Age distribution of renal tx in Nordic children
8
Pediatric renal transplantation in the Nordic countries
9
Pediatric renal transplantation in the Nordic countries
Dialysis before 1st transplantation
  • Norway ~48%
  • Sweden ~56%
  • Denmark ~72%
  • Finland ~98%
10
Pediatric renal transplantation in the Nordic countries
11
Pediatric renal transplantation in the Nordic countries
Age distribution/year
12
Age distribution of renal tx in Nordic children
13
Pediatric renal transplantation in the Nordic countries
Patient survival
14
Pediatric renal transplantation in the Nordic countries
Causes of death (n=12)
  • Related to transplantation
  •   time aft tx
    n (months)
  • Lymphoma 2 12.5, 2.7
  • Rej. + sepis 1 21
  • Mal. due to 1 8.9
    imm.suppr
  • Resp. arrest 1 8.6
    (paralytic ileus)
  • Pneumonia 1 3.8
  • Seps. + MOF 1 0.8



  • Not related to transplantation
  •   time aft tx
    n (months)
  • Cerebr haem 1 42
  • Traffic accid. 1 12.2
  • Recurr. HUS 1 3.3
  • Liver failure 1 0.1
    (liver tx)
  • No info 1 91
15
Pediatric renal transplantation in the Nordic countries
Graft survival
16
Pediatric renal transplantation in the Nordic countries
1 year graft survival
17
Pediatric renal transplantation in the Nordic countries
Age distribution/year
18
Pediatric renal transplantation in the Nordic countries
19
"Transferred to adult unit"
  • Transferred to adult unit 35
20
Pediatric renal transplantation in the Nordic countries
Initial immunosuppression
  • CyA, Aza, Pred 194 (58%)
  • Tac, Aza, Pred   52 (14%)
  • CyA, MMF   28 (8%)
  • CyA, Pred   27 (7%)
  • Tac, MMF, Pred   21 (6%)
  • Tac, Pred   13 (4%)
  • CyA, MMF, Pred   11 (3%)

  • + a couple of other combinations with only a few patients in each group
21
Pediatric renal transplantation in the Nordic countries
Initial immunosuppression
  •        (+ Simulect)   (+ Zenapax)
  • CyA, Aza, Pred 194 (40)
  • Fk, Aza, Pred   52
  • CyA, MMF   28
  • CyA, Pred   27 (15)
  • Fk, MMF, Pred   21 (3)          (3)
  • Fk, Pred   13 (6)
  • CyA, MMF, Pred   11 (1)

  • + a couple of other combinations with only a few patients in each group
22
Activities in NPRTSG
  •   Workshops
  • Helsinki General discussion
    May 2000
  • Copenhagen Pre-emptive transplantation vs
    January 2001 dialysis
    Obstructive uropathy
  • Oslo Hypertension
    January 2002 Immunosuppressive protocols
  • Helsinki Renal tx in small children
    January 2004
23
The Nordic Pediatric Renal Transplant Study Group
  • Aarhus M Madsen Odense B Jespersen
    N Rohr
  • Copenhagen S Sørensen Oslo A Kyte
    B Lien
  • Gothenburg S Hansson Stockholm U Berg
    S Friman G Tydén
  • Helsinki C Holmberg Uppsala K Claesson
    K Salmela T Nevéus
  • Malmoe D Karpman
    NH Persson Coordinator M Larsson